Moods as ups and downs of the motivation pendulum: Revisiting Reinforcement Sensitivity Theory (RST) in Bipolar Disorder

Motivation is a key neurobehavioral concept underlying adaptive responses to environmental incentives and threats.As such, dysregulation of motivational processes may be critical in the formation of abnormal behavioral patterns/tendencies.According to the long standing model of the Reinforcement Sensitivity Theory (RST), motivation behaviors are dr

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Computational investigations on target-site searching and recognition mechanisms by thymine DNA glycosylase during DNA repair process

DNA glycosylase, as one member of DNA repair machineries, plays an essential role in correcting mismatched/damaged DNA nucleotides by cleaving the N-glycosidic bond between the sugar and target nucleobase through the base excision repair (BER) pathways.Efficient corrections of these DNA lesions are critical for maintaining genome integrity and prev

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